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KMID : 0366220060410030215
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Korean Journal of Hematology
2006 Volume.41 No. 3 p.215 ~ p.219
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A Case of Mantle Cell Lymphoma Treated with Autologous Stem Cell Transplantation and Rituximab
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Oh So-Yeun
Jang Moon-Ju
Chang Sei-Kyung
Oh Do-yeun
Chong So-Young
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Abstract
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Mantle cell lymphoma is a subtype of aggressive non-Hodgkin’s lymphoma and usually presents in advanced stages. When treated with a regimen such as CHOP, the median survival is about three years. More aggressive front-line therapy with the hyper-CVAD regimen or high-dose therapy with stem cell support has shown encouraging results in several trials. The addition of rituximab to the chemotherapy regimens, or high-dose therapy, increased the response and survival rates in patients with mantle cell lymphoma. We report a case of mantle cell lymphoma that was successfully treated with aggressive front-line treatment strategies. The patient achieved complete remission with initial hyper-CVAD regimen, and was consolidated with autologous stem cell transplantation and subsequent rituximab.
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KEYWORD
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Mantle cell lymphoma, Hyper-CVAD, Rituximab, Autologous stem cell transplantation
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